RESUMEN
OBJECTIVE: To evaluate whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19. METHODS: We present a post hoc analysis from a double-blinded placebo-controlled randomized clinical trial (RCT) on the effect of colchicine for the treatment of COVID-19. Serum levels of NOD-like receptor protein 3 (NLRP3) inflammasome products-active caspase-1 (Casp1p20), IL-1ß, and IL-18-were assessed at enrollment and after 48-72 h of treatment in patients receiving standard-of-care (SOC) plus placebo vs. those receiving SOC plus colchicine. The colchicine regimen was 0.5 mg tid for 5 days, followed by 0.5 mg bid for another 5 days. RESULTS: Thirty-six patients received SOC plus colchicine, and thirty-six received SOC plus placebo. Colchicine reduced the need for supplemental oxygen and the length of hospitalization. On Days 2-3, colchicine lowered the serum levels of Casp1p20 and IL-18, but not IL-1ß. CONCLUSION: Treatment with colchicine inhibited the activation of the NLRP3 inflammasome, an event triggering the 'cytokine storm' in COVID-19. TRIAL REGISTRATION NUMBERS: RBR-8jyhxh.
Asunto(s)
COVID-19 , Inflamasomas , Humanos , Inflamasomas/metabolismo , Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo , Interleucina-18 , Proteínas NLR , Colchicina/uso terapéutico , Interleucina-1beta/metabolismoRESUMEN
The Covid-19 pandemic caused sudden changes in the social, political, economic, and educational fields in Brazil and worldwide. One of the measures implemented is the shutdown of schools during physical isolation, which challenged them to assume distance learning on an emergency basis, mediated by digital technologies. In this sense, this article aimed to analyze how the school can fulfill its political and social function in the context of the pandemic crisis. From the methodological point of view, it is an exploratory study with a qualitative approach with secondary and empirical data from UNESCO. There was also a mapping of Brazilian states on the conduct of education during the coronavirus pandemic. The results indicate that the new coronavirus pandemic has had different implications for social life;emergency remote education implemented in most Brazilian states did not count on the participation of the school community.